Black Sauve
In the 1850s, American surgeon Jesse Fell learned of a plant used by Native Americans to treat cancer. He identified this plant as bloodroot and subsequently combined it with zinc chloride to formulate Fell’s Paste. On emigrating to London, Fell established a lucrative cancer practice using this paste but was ridiculed as a humbug by many in the medical establishment.
Harry Hoxsey, an Illinois insurance salesman, began selling cancer treatments, including an escharotic in the 1920s. Hoxsey’s red paste contained antimony trisulfide, zinc chloride and bloodroot and it was reportedly developed after observing horses cure themselves of cancerous lesions by grazing on certain plants. Hoxsey opened 17 clinics across the US, treating several thousand patients in a multi-million dollar enterprise. The American Medical Association branded Hoxsey a charlatan, and the US Food and Drug Administration (FDA) mounted warnings about Hoxsey’s formulas in 46,000 US post offices.
Dr Frederick Mohs noted in the 1930s that zinc chloride fixed and histologically preserved skin in vivo. Mohs developed a paste that used stibnite and bloodroot to maintain zinc chloride in suspension, enabling it to act uniformly as a fixative. By microscopically mapping entire tumour margin involvement and excising until clear margins were obtained, Mohs produced cure rates of 99.3% in 7257 cases of basal cell carcinoma (BCC) and 94.4% in 2551 cases of squamous cell carcinoma (SCC). However, these results were not due to Mohs’ paste constituents, as evidenced by similar cure rates with the subsequently developed fresh tissue technique where escharotics were not used. Mohs patented his paste to prevent its improper use as a standalone topical therapy.
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